Clinical Efficacy of Diammonium Glycyrrhizinate on Drug Induced Liver Injury and Influence on Related Inflammatory Factors

To assess the clinical efficacy of diammonium glycyrrhizinate on drug induced liver injury and its effect related inflammatory factors in real world. A total 234 inpatients diagnosed with our hospital were continuously enrolled this retrospective world study, whom 110 treated divided into three groups according to combination. Treatment group (n=34) received injection+reduced glutathione injection, treatment B (n=45) Kuhuang injection based administration for A, C (n=31) ursodeoxycholic acid capsules B. The remaining 124 cases did not undergo treatment, including 37 control receiving reduced alone, 55 32 lasted 2 w. biochemical indices such as serum gamma glutamyl transpeptidase, bilirubin, alkaline phosphatase, glutamic pyruvic transaminase, tumor necrosis factor-α interleukin-6 observed before 1 w after adverse reactions recorded. was evaluated compared. Compared levels factor-α, bilirubin B, transpeptidase all significantly declined (p<0.05). (p<0.05), while changes had no significant differences other (p>0.05). but level rose response rates higher than those respectively it lower that exceeded (p<0.167), difference between (p>0.167). mild alone (control A) injection+Kuhuang B), double combination injection+diammonium (treatment triple B) can improve function increase rate, a rate quadruple injection+ursodeoxycholic capsules+diammonium C). significance each safe.